From the README, for those who didn't scroll that far:
"While Codon supports nearly all of Python's syntax, it is not a drop-in replacement, and large codebases might require modifications to be run through the Codon compiler. For example, some of Python's modules are not yet implemented within Codon, and a few of Python's dynamic features are disallowed. The Codon compiler produces detailed error messages to help identify and resolve any incompatibilities."
"While Codon supports nearly all of Python's syntax, it is not a drop-in replacement, and large codebases might require modifications to be run through the Codon compiler. For example, some of Python's modules are not yet implemented within Codon, and a few of Python's dynamic features are disallowed. The Codon compiler produces detailed error messages to help identify and resolve any incompatibilities."