I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medicines"
You won't do it at the same doses as cancer treatment protocols .
I've been doing rapa for my mood issues stemming from inflammation for some years now and low doses similar to the doses seen in recent studies for age longevity with no apparent side effects .
A large amount of rapa was bought during a group buy
It was devided up between people who couldn't afford or get it
To be clear its not specifically an anti cancer med it's an immune suppressant. It targets mtor so it's great for autoimmune disease
The group I belong to specifically are people that have diseases that couldn't be treated either because of financial reasons or because docs wouldn't prescribe meds off label so we resort to such methods .
So no actual medical professionals involved. Got it. Please start your comments with that, though. You do you, but last I remember I’ve never seen a single person who desperately tried to live long actually live long.
I'm not sure why you didn't take the time to read the comment you replied to, but still, if we modify your statement a little:
> I’ve never seen a single person who desperately tried to live long actually live long
to I’ve never seen a single person who desperately tried to live longer actually live longer it changes from something you can't believe to a statement we know to be false because we see people achieving it every day, and that's what @jokowueu is attempting to do, and good luck to them.
The vibe I get off of Aubrey de Grey is not here’s a man who wants to live forever, so much as here’s a man afraid of dying. And these days he’s starting to look like an origin story for a lich. He’s 5% ghoul and climbing. He needs Buddhism, not anti cancer drugs.
Once in a great while I see a movie character who wants to see how the story ends. Most of the rest and most of the real humans want to cheat death, which is a very different sentiment.
Would be interested in your experience with fluorometholone eye drops. On-label for itchy eyes, but off-label seems to rapidly (onset ~ 60 seconds) reduce brain inflammation temporarily leading to mental quiet. Can't use too much tho as the steroid will dull the immune system in your sinuses increasing infection risk.
I know someone who played Russian Roulette once and is still alive. Getting lucky and risk taking have been best friends since the dawn of time.
Side effects don’t hit everyone and they don’t hit everyone the same. I’m on the absolutely lowest dose of a prescription drug because I react strongly to it. First dose had a really unpleasant side effect, lower dose got rid of that one but another developed later. It wasn’t particularly bad, I just found it upsetting. Lowest dose still gets most of the benefit without the side effects. For me. I know of someone with panic disorder who has a long list of drugs they can’t take at all because “feels funny” is enough to trigger an attack. We suspect vagus nerve issues of some sort.
I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medicines"