Right. Some of these potential longevity interventions seem to have a catabolic effect. Not a problem if you're a mouse living in a safe, flat lab cage. But problematic for an elderly human at risk of falling down the stairs and breaking a hip due to sarcopenia.
It's just a general trend. The strength of the catabolic effect will depend on the specific intervention and dose. The risk is greatest for non-athletes because they tend to be weaker to start with and more likely to experience disabling falls as they age.
