I use a 7x USB 3.0 expansion card for my gaming system, because I hate hot-plugging input devices into my front panel I/O. My gaming uses a mix of peripherals from a Keyboard and Mouse (separate from the ones I use for productivity work on the same PC) to an Xbox controller to a HOTAS & Pedal kit, plus charging cords for my Valve Index controllers that I leave plugged in and routed. And of course high-end gaming headsets usually use USB these days, plus a webcam. I use a lot of ports. :)
Recently I had some USB enumeration loop (turned out to be the Index umbilical connector) that made me disconnect everything one by one. What a marathon. The USB hub dedicated to wireless dongles alone has a wireless keyboard/touchpad adaptor, the one of the Steam Controller and an ANT+ stick. Elsewhere the homebrew stick/rudder is linked up, the Nrf52 devkit, keyboard, mouse, another touchpad, the hub where I connect Android devices for development and occasionally a Garmin for some cIQ stuff. A modified webcam I used to use for infrared headtracking and that cheap portable usb audio with built in phantom power for a condenser mic headset (the firewire audio interface seems to be acting up). The old laser printer is permanently connected whereas the scanner is only plugged in on demand. Currently disconnected are the throttle quadrant, the trim box (with yet another touchpad, still ps/2) and the midi controller. Somewhere there's an arduino configured as an nrf52 programmer. Yes, I need a notebook computer free of most of that stuff to get actual work done.
And if you get 3x full body vive trackers for your index, those each have a USB receiver and you need 3 more ports and they can't be consolidated for some reason. And if you want to charge those from your computer, that's 3 more ports.
I have an anker 5-port USB power hub (no data, not connected to computer) next to my machine for charging phone, headphones, earbuds, etc, and another 10-port hub for charging the 2 index controllers, 3 full body trackers, and 3 track straps with builtin batteries for extended play (for days when you feel like spending more than 7 hours in VR anyways...)
