I'd like a PCIe card with room for more NVMe drives on it. I'd like to replace my SATA connected SSDs for performance, but I can only stick two M2 cards on my motherboard.
Highpoint and Squid are your goto options in that space. There are others, e.g. dumb cards, if you just want to bifurcate an existing PCIe slot to handle four M.2 drives. But if you want 16 or 64 NVMe drives, the two manufacturers I mentioned have offerings. I have a Highpoint U.2 card, which gives me the option to handle 8x U.2 or M.2 drives (with adapters) in a single PCIe slot.