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>Sorry but in terms of obesity and weight loss, it's really not more complex.

No, it is extremely complex. "Calories in < Calories out" isn't even stating the principle you think it is. You want to make a statement about fat balance depending on calorie deficit, independent of what type of food you eat, and even that is completely wrong. Different foods take completely different paths through the human digestive system (e.g., fructose vs. glucose) and thus have completely different effects independent of their "calorie" count. Most people on a calorie deficit are not also exercising, and their weight loss is 25% muscle loss, which is a disaster for their future health.

Peter Attia makes a careful statement about "calories in/calories out" in the first few minutes of this lecture: https://youtu.be/31g94p5J2gE

Doug McGuff covers med school biochemistry and metabolism in the last part of this presentation, and mentions "internal starvation" where obese people crave food at regular intervals, but the food goes directly into fat tissue. https://youtu.be/2PdJFbjWHEU

Hey, if it is just calories in < calories out, why is Bill Gates so much richer than me? All he did was spend less than he earned, right?




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