On: AlphaFold reveals the structure of the protein uni...

[candiddevmike]

Is folding@home obsolete now?

[flobosg → candiddevmike]

Folding@home answers a related but different question. While AlphaFold returns the picture of a folded protein in its most energetically stable conformation, Folding@home returns a video of the protein undergoing folding, traversing its energy landscape.

[dekhn → candiddevmike]

It's not, but the question is (and has long been) whether the energy expended by folding@home is worth the scientific result. IMHO- probably not.

[foxhop → candiddevmike]

I would say no, the two approaches may be used to validate each other.

[seventytwo → candiddevmike]

Good question… I’d imagine that other methods of folding solutions are still valuable, because AlphaFold needs to be checked.