Artificial sweeteners are by definition fake sweet. They are lab-discovered chemicals that short-circuit our sugar-detection mechanism, the taste of sweetness, which explicitly evolved to detect sugar, which artificial sweeteners are not.
Not deeper than a surface level understanding of evolutionary biology, no. Apparently nobody knew how sweetness works until 2001 when researchers found the specific protein that detects sweetness, and then 2012 when the receptors for that protein were figured out.
Just think about that. Until ten years ago, nobody even knew how sweetness works, yet artificial sweeteners have been in use for 50.
