Anecdotally, I've used HiDPI alongside 1x res monitors since 2015 now, and I can honestly say I don't care much about which one I'm using for reading and writing.
What does matter though is gray uniformity and the size of the color gamut. Especially for the work I do (video and photography).
I always disable this crap, fine with pixels %)) OK, I understand pixel interpolation is useful in printed media production, but on displays... Win95 still looks great to me.
Well, people have different opinions about it. I personally hate visible pixels with passion. I was an early adopter of HiDPI displays (starting with IBM T221 back in 2007), and I don't understand how anybody could settle for less after they see this gorgeous high resolution.
It's probably the fact that most people haven't experienced it. Regular consumers think macbooks have magically "better" displays than most windows laptops but can't name the exact reason. But just getting a high DPI laptop/monitor gets the same effect.
https://en.wikipedia.org/wiki/Subpixel_rendering