On: New CRISPR-based map ties every human gene to its ...

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You may also be interested in the Yeast 2.0 project,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894084/

which is an attempt to redesign the genome of the model organism S. cerevisiae, i.e. standardize codons, remove junk DNA, etc.