The weak link in all these setups is the mouse. Hilariously weak.
"You can use your hand like a hook supporting your arm, with your hand itself transferring the weight onto the edge of the mouse pad."
Really? Seriously? This is one of the least ergonomic things imaginable.
Just use a trackpad and a lot of these problems go away. Trackpads are superior anyway, and you can fix them into a position, you don't have to make all kinds of large motions with your entire arm while holding your arm's weight up, etc.
Not actually subjective. Massively superior to avoid all that unnatural wrist movement, and trackpads enable multi-finger gestures of all kinds that a mouse can't do. Meanwhile you have more precision with much less motion.
And for this particular application, it should be quite easy to see that a mouse requires a mouse pad, and relies on being used in the wrong plane, because of gravity, whereas a trackpad can be anchored, takes up a lot less space, and can be used in any plane.
"You can use your hand like a hook supporting your arm, with your hand itself transferring the weight onto the edge of the mouse pad."
Really? Seriously? This is one of the least ergonomic things imaginable.
Just use a trackpad and a lot of these problems go away. Trackpads are superior anyway, and you can fix them into a position, you don't have to make all kinds of large motions with your entire arm while holding your arm's weight up, etc.