Funnily, I find the idea that a susbstance can influence your behavior so much rather depressing :( is there anything there that is fundamentally unchangeable no matter the chemistry that could be called a "self".
"is there anything there that is fundamentally unchangeable no matter the chemistry that could be called a "self""
The Buddhists don't think so. One of their fundamental tenets is "anicca" or "impermanence", which is often interpreted to mean that nothing is unchangeable or everlasting.
Many materialists/naturalists/physicalists don't believe there's an unchanging self either.
But those who believe in a soul, in resurrection, or in reincarnation might.
It's not a settled question, and a lot depends on what you mean by "self".