There seem to be industries that cannot be disrupted by dumping hundreds of millions of VC dollars on PR and marketing and undercutting the competition until you're the last man standing. Health care and pharma for one, I'd say aerospace as well (exceptions like SpaceX notwithstanding, and they have a top notch team and Shotwell who seem to be perfectly able to manage both an aerospace company and its tech bro founder).
The formula of "dumping hundreds of millions of VC dollars on PR and marketing and undercutting the competition until you're the last man standing" work on industries that had no "difficult problems" to solve in the first place, and only need marketing and scale.
It's not a coincidence that the companies that succeeded with the formula were internet ads, and monopolies that provided day to day services (replacing mundane stuff like taxis, hotels, social interaction, etc...)
