Skype, Facebook, Zynga, Twitter, Jawbone and Box.net are all in the Andreeson Horowitz portfolio. He seems to be doing fine.
He bought FB way too late than most others. What valuation did he buy in Zynga, Twitter etc than we'll talk? Jut because they're 'hot' now doesn't mean that they'll make him money later.
Of note, he's also on the HP board of directors