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Isaac Newton: His work on calculus, optics and gravity was all done in isolation (the university was closed as a precaution against the plague).



He supposed to have said "If I have seen further than other men, it is because I stood on the shoulders of giants." . But this may just have been a mean comment at the expenses of his small-of-stature rival, Hooke. (Newton was both a genius and an arsehole)




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