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Makes me wonder if this was discovered in mice engineered for inducible gene expression. TET/doxy mice are commonly used in experiments where you want to selectively turn on or off a particular gene.

https://pubmed.ncbi.nlm.nih.gov/27216914/




I might be wrong, but I think that TET enzymes and the Tet-Off/Tet-On system are not related.





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