Aspirin reduce inflammatory response, which testosterone also do. The more likely reason why Aspirin helps to improve lifespans in men is that it steps in when testosterone has fallen through aging, stepping in to do the role of testosterone. High inflammatory response can be quite deadly, especially in connection with cardiovascular problems (a common cause of death for men).
17αEstradiol is a weaker form of estrogen. Men that has either too high or too low amount of estrogen has an significant increase in heart failure. When testosterone goes down during old age, estrogen tend to also go down as estrogen is produced in men through converting testosterone. Again it seems that the drug can help by stepping in after a fall in testosterone.
NDGA (nordihydroguaiaretic acid) is an xenohormone that imitates estrogen. See above about estrogen.
Protandim is a mix of five herbs, including green tea. Can't tell anything about that, and FDA has issued a warning against the manufacturer for false claims.
I don't think the 17a estradiol effect is due to classic estrogenic activity. But probably due to ER-X activation which helps correct metabolic abnormalities in men.
