I deployed a Py application (Pandas, PyQT) at work. It was horribly slow on half of the Windows machines ,likely because of the antivirus but I didn't have admin rights to check that. It was impossible to make a single file exe because it took too long to decompress. I spent days trying to reduce all the unused files half-manually (because automated approaches kept failing). In the end I threw all of that out , rewrote the UI and deployed it as a web application on a server. Now the users are happy.
