It's harder than you think, and remember that the consequence is not “I can't play a game until I revert my config” but “I was reported to my college for an ethics violation and now my $$$ degree is in question” or “My professional organization has been told that I attempted to cheat and the certification I need to keep my job is in jeopardy”.
There are many things which are technically possible which are not a favorable cost-benefit for most people. This is in the same category as those guys who relied on technically being able to fly without showing ID to the TSA — there's a reason why it was mostly affluent white men flying solo, because the potential downsides are much greater for most other categories.
KVM is probably your best bet on Linux and VMware the best on Windows.
https://github.com/hzqst/VmwareHardenedLoader works for VMware but doesn't work against some modern anti-cheats, but KVM universally works against anti-cheats when configured properly with RTDSC spoofing and such
