I don't think this question is answerable so abstractly. It really depends what you're trying to build and what the technical constraints are.
There are so many architectures, API approaches, frameworks, and languages these days. Almost any one could be argued as being better or worse off of different criteria.
Also Django being batteries included makes most comparisons very apples to oranges. Even comparing a basic CRUD web app / API in Django + DRF to Flask means pulling in like a dozen packages to help vs just the one with Django.
In the world of Python web frameworks specifically, FastAPI is really nice these days for a lot of REST API type use cases.
There are so many architectures, API approaches, frameworks, and languages these days. Almost any one could be argued as being better or worse off of different criteria.
Also Django being batteries included makes most comparisons very apples to oranges. Even comparing a basic CRUD web app / API in Django + DRF to Flask means pulling in like a dozen packages to help vs just the one with Django.
In the world of Python web frameworks specifically, FastAPI is really nice these days for a lot of REST API type use cases.