The Kintex-7's are much bigger than the Spartan 6's. Getting a 6502 core into them wouldn't be the issue. The special thing about this board, though is that it's designed to be pin compatible with a real 6502 CPU, so you can plug it straight into a real 1970's/1980's home computer that used a 6502. If that's not what you want to do you'd need other glue logic to interface the CPU core with whatever you want to interface it with.
