But I think the point is not that they found a chemical that can inhibit CA, it's the idea that targeting CA could be useful. From that point of view, CA dependence really is the "Achilles' heel" of tumors, since tumors (presumably) require vascularization, CA prevents hypoxic regions from acidifying and CA inhibitors will halt tumor growth.
If the initial chemical this team found is not good, no problem, another can be found.
Interesting that I found, on a hunch, that aspirin is also a CA inhibitor[0] (could explain some of its cancer-reducing effect), and further that aspirin derivatives are also promising CA inhibitors[1] (targeting CAIX).
Putting all that together it seems there's a ripe avenue of research for targeting the Achilles' heel of tumors: find CA inhibitors derived from already well-tolerated cheap widely available generic drug (aspirin), and pursue those that are safe and effective in humans. I'm optimistic! :P ;) xX
If the initial chemical this team found is not good, no problem, another can be found.
Interesting that I found, on a hunch, that aspirin is also a CA inhibitor[0] (could explain some of its cancer-reducing effect), and further that aspirin derivatives are also promising CA inhibitors[1] (targeting CAIX).
Putting all that together it seems there's a ripe avenue of research for targeting the Achilles' heel of tumors: find CA inhibitors derived from already well-tolerated cheap widely available generic drug (aspirin), and pursue those that are safe and effective in humans. I'm optimistic! :P ;) xX
[0]: https://www.mdpi.com/2218-273X/10/4/527
[1]: https://pubmed.ncbi.nlm.nih.gov/33844134/