I think it would be fascinating to know more about the anabolic/metabolic pathways that create these molecules. Could it be we are seeing similar products created as mutations of core synthetic pathways?
It's important to understand that the venom of Bufo alvarius (the Colorado River toad)[1] contains 5-MeO-DMT, not NN-DMT. It is NN-DMT that is colloquially known as "DMT", and the two substances should NOT be confused.
They are very different in effect, though closely related chemically.
5-MeO-DMT is widely considered to be by far the most powerful psychedelic on the planet. NN-DMT is considered to be much more powerful than traditional psychedelics like LSD and psilocybin, but still a pale shadow compared to 5-MeO-DMT. NN-DMT is a lot more visual than 5-MeO-DMT, while the latter is considered to be much more likely to lead to states of non-dual awareness and ego-death.
For more information on 5-MeO-DMT see: [2]
Something else to note about the bufo alvarius venom: these toads are under threat and might well go extinct because they're being recklessly exploited for their venom.[3]
Furthermore, their venom contains a lot of other compounds apart from 5-MeO-DMT, some of which are known to be toxic when ingested. So it should always be smoked, never ingested! Even when smoked the venom could cause health problems for people with heart conditions. The synthetic form of 5-MeO-DMT only consists of 5-MeO-DMT itself, so has none of these problems, though people with heart conditions should probably still avoid even the synthetic version.
Finally, some people who style themselves "DMT shamans" use very dangerous practices like pouring water in the mouths of people who are essentially unconscious under the influence of 5-MeO-DMT, mixing drugs, slapping and kicking people under the influence, and covering their mouth and nose... fatalities have resulted from these dangerous practices.[4] So if you are considering trying this substance very carefully vet who you do it with!
I strongly recommend reading and following the guidelines from The Conclave.[5]
I think it would be fascinating to know more about the anabolic/metabolic pathways that create these molecules. Could it be we are seeing similar products created as mutations of core synthetic pathways?