The biggest desk/workstation upgrade I have had in years was putting my monitor onto a wall-mounted arm. The desk space under the monitor magically opened up into a vast empty plain that I could then fill up with... more cables. But at least I can do more now :-)
Along the same lines, have somewhere to put your keyboard and mouse.
Bam! You now have a full normal desk to draw, paint, glue stuff, solder etc.
I live in a 2 bed apartment with a 3 year old. My desk is an Ikea Ivar shelf with the computer sitting on the highest shelf to keep it all away from my toddler...