> if you mainly live in a web browser and don't do GPGPU
For what it's worth, I use Guix and I've been able to do everything but CUDA just fine. (CUDA will never be supported in Guix as it requires proprietary drivers to function.) There are opencl packages, for example. It works well enough to run an Ethereum miner, Blender, and even games in WINE. I've been meaning to package AMD ROCm for better GPU compute support.
For what it's worth, I use Guix and I've been able to do everything but CUDA just fine. (CUDA will never be supported in Guix as it requires proprietary drivers to function.) There are opencl packages, for example. It works well enough to run an Ethereum miner, Blender, and even games in WINE. I've been meaning to package AMD ROCm for better GPU compute support.