As somebody who has a somewhat strange form of Multiple Sclerosis wherein almost all of the damage is in my so-called "water channel" nerves located in my optic nerves and around my brain stem, the observation that pathogens get "swept" into the area of my CNS where most of my lesions occur is very interesting. I've been tested multiple times for neuromyelitis optica, but that's come back negative each time, so it's still officially diagnosed as MS. It's just that my white matter has been completely untouched for the 23 years I've had symptoms, which is really unusual.
Interferon beta worked really well for me, and now Ocrelizumab is doing even better.
I'm convinced that what we call "Multiple Sclerosis" today is actually a collection of distinct conditions with largely orthogonal causes, and just about the best we can do in absence of a more thorough understanding of the issues is nuke all the adolescent B-lymphocytes (which is what Ocrelizumab does).
My last test for NMO was a little over a year ago. It was definitively negative. I'm responding really well to Ocrelizumab, which my neurologist tells me would probably be what he would treat me with for NMO too, so it's sort of a moot point for me whether it's MS or NMO. Treatment is the same, outcomes are the same.
I'll look into it. Although the nerve damage is in the CNS and not peripheral, and I don't have any issues with dry eyes and mouth. Fifteen MRIs and 5 different neurologists have all pegged it as MS.
Ouch. That's no good but glad they narrowed it down. I've always had read areas under my eyes and dry eyes, and now dry skin on my forehead and around my mouth.
Back to OSA: I have tachycardia and hypertension controlled by a beta blocker (propranolol er). Also, depression, ADHD, and (physiological) anxiety. Can't and could never run a mile to save my life. Haha. Could/can do explosive intensity exercises but never anything more than very low intensity like walking or bicycling.
I wondering if I have pulmonary and/or circulation issues on top/because of OSA that limit moderate aerobic exercise capacity. (Heart is unremarkable per 12-lead ECG, stress echo, and catheterization at Stanford Cardiology a few years ago.. actually performs very efficiently under load.)
> The new findings help clarify one detail of Shirai’s 1921 mouse study that never sat well with the naive notion of immune privilege. Shirai found that tumors survived and grew when implanted in some locations in mice’s brains. But when Shirai placed tumors right next to the ventricles — now known to be the locations where the brain produces the fluid that sweeps antigens off to the immune cells — the tumors didn’t survive.
So, the key experiment to reveal this fact was performed one hundred years ago, but overlooked.
Yes, a pretty big oversight by anyone on the design team concerned with security. It just makes it look like humans were yet another product pushed out the door before they were ready for prime time.
I don't know, not every aspect of our biology is an evolutionary advantage. Some just didn't have enough of a negative impact to get weeded out over time. For example we're rather squishy. Considering that built-in armor is a known-feature of other animals, the devs could have added that into the release. Honestly I would expect "not squishy" to have been in the initial human MVP release. I mean, they figured out that the mouth input channel needed to occasionally be used as an emergency output-- they had some idea of what they were doing, but still missed some obvious things.
Then again, if we're being developed by an evolutionary algorithm, why should I assume we're a full version release? It's possible we're still in the alpha stage. Or possibly some other developmental culdesac that just hasn't been pruned yet. We could be one of many incorrect answers to a recursive depth-first search algorithm, each iteration of which uses incremental parameter changes for the input of the evolutionary algorithm. Some dev one level up in the layers of reality might be getting yelled at right now for not using a breadth-first approach, or for using a resource intensive evolution process when the client just needed something "good enough".
It is open source. You can go ahead and download the human genome. You just can't run it because of a lack of efficient simulation, and unlike human-created code the code is both obfuscated and lacks clear separation of intents.
yeah its a code base millions of years old consisting of spaghetti code with no comments written in a turring tarpit of a language that compiles directly to hardware with ridiculous compile times
Yeah, every time someone says I need to believe in God, I tell them that I want to believe, if only to get there and punch them in the face for creating such bullshit :D
The GPL makes this "binary" vs "source" distinction by talking about the "preferred form for making changes". Well, the binary blob of DNA happens to be also be the source!
Feel free to publish your genome under an open source license =)
It's open source if you git clone the adaptive part and put it on Github. There's just a bunch of IP restrictions on your own genes because plutocracy. Apache license then?
I lost the compiler though, so it might as well be a binary amoebic blob, but I hear you can throw mRNA at the API to teach it new tricks.
>Fasting: stop dicking with the code and lets see if the error reoccurs.
>Dietary Restrictions: I added a new linter! Now you can't commit crappy code!
>Sleep Hygiene: This...sleep thing... You're saying if I learn to lucid dream, I can figure out problems while I sleep?
>Exercise: Yessssss! 100% test coverage.... Wait, are we talking the code, or me?
>Actual hygiene: Keyboards. Are. Disgusting.
>Spartanism: I live in an office with a desk, three screens a chair, and maybe a mat. No, I bear no ill will towards ancient Athens, or the rug... Why do you ask?
"Yes. You should always be working on business problems while you are sleeping under your desk. That's why we pay you the big bucks salary... so your hourly rate is less than a retail store cashier's and your soul is ours... forever! Hahahah."
> Exercise.
Test coverage and typing doesn't count. )': Must. Paump. Zie. Iiron because Hanz und Franz zays zo.
> Keyboards.
We only buy dishwasher-compatible keyboards now and have a dedicated dishwasher for them. The cleaning people collect them every Friday night. https://youtu.be/pgnF42ZoRSw
Interferon beta worked really well for me, and now Ocrelizumab is doing even better.
I'm convinced that what we call "Multiple Sclerosis" today is actually a collection of distinct conditions with largely orthogonal causes, and just about the best we can do in absence of a more thorough understanding of the issues is nuke all the adolescent B-lymphocytes (which is what Ocrelizumab does).