Always, if used correctly. i.e. = in other words, e.g. = for example. Surely, as...

alvah on Feb 2, 2021 | parent | context | favorite | on: A 25-Year-Old Bet Comes Due: Has Tech Destroyed So...

Always, if used correctly. i.e. = in other words, e.g. = for example. Surely, as a native English speaker, you can see the huge difference? One is definitive, the other is presenting one or more examples.