The easiest way to test printing at an angle is to rotate the object 45 degrees before printing; you'll need a lot more supports, but it can be done.
The results depend on the forces your object will see. The tensile strength is lower perpendicular to the printing direction, as the adhesion between layers is lower than the continuous filament adhesion. So printing at an angle is better if you need more tensile strength on the Z axis (but then you can rotate it to have that axis flat), but it also reduces the strength on that angled direction.
The results depend on the forces your object will see. The tensile strength is lower perpendicular to the printing direction, as the adhesion between layers is lower than the continuous filament adhesion. So printing at an angle is better if you need more tensile strength on the Z axis (but then you can rotate it to have that axis flat), but it also reduces the strength on that angled direction.