Hacker News new | past | comments | ask | show | jobs | submit login

I guess this could be a good treatment for people who have severe symptoms. Or maybe they can find a way to prevent the hallucinations or create a similar drug without those effects. Otherwise, it seems like the person would be injected every other day and lose most of that day to side effects.



Funnily, drinking ayahuasca often actually has a reverse-tolerance effect (ayahuasqueros tend to be incredibly sensitive to its effects)


It is possible. You simply drink extract of the vine in small doses. As westerners we are a little obsessed with the hallucinatory effects which comes from the chacruna (leaf). The spirit of the medicine comes almost entirely from the vine. A drop of extract of banisteropsis caapi in water in the morning often provides more gentle results without the hallucinations.


What type of dose do you get in ayahuasca? The 2mg/kg from the test seems like a substantial amount.

If the hallucinations come from another plant, then why does the paper say DMT is classified as hallucinogenic?


The Hallucinations do come from DMT, but many MAOIs present their own sensations and properties that are more "emotional" instead of hallucinogenic.

They were the first anti-depressants available after all!


DMT lasts about fifteen minutes, and is completely over after an hour.


Oh. Then I guess it's the other ingredients that can make ayahuasca last for 4-6 and induce vomiting. Good to know.


Vaporized DMT lasts about 15 minutes. Orally ingested DMT+MAOI lasts about 4-6 hours with hour 1-3 being the most intense. In terms of this study I'd be interested to see if there's a difference between the two.


This study is injecting it, but I'm not sure what route they would take on humans.


Why is this downvoted?




Consider applying for YC's W25 batch! Applications are open till Nov 12.

Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: