I'm surprised (okay, maybe completely unsurprised) just how much evidence keeps pointing me towards the same conclusion about how to maximize for a long, fulfilled life: all things in moderation.
The trouble with "everything in moderation" is that moderation is an ambiguous, catch-all term. It means different things to different people. It's the mantra of the obese and unhealthy.
Ultimately we strive for moderation, but ought not without consideration as to what it should entail.