I ran 5 USB drivers (4x USB3 and 1x USB2) of a powered USB3 hub attached to a RPi4 a few weeks back as was clearing up some drives and data juggling between them. Had that running for few days with no issues at all and was thrashed a few times with moves/copies across all the drives.
So indications are good, and the drives in this case was a WD SSD, 3x Toshiba bus powered drives and an ancient 320gb usb externally powered WD affair. So a but of a mix. Though I did have it plugged into a UPS, which like all things tech - kinda helps smooth out the random chaos of electricity and tech.
Most storage corruption problems related Rasberry PIs are just PSU problems. Flash drives and SD cards draw their power directly from the Rasberry PI and since those only use a crappy micro USB port or a buggy USB C port you're going to run into issues, especially if you use a random USB charger instead of the official power supplies. External storage like an SSD that uses its own power supply (via the USB hub) will be far more reliable.
So indications are good, and the drives in this case was a WD SSD, 3x Toshiba bus powered drives and an ancient 320gb usb externally powered WD affair. So a but of a mix. Though I did have it plugged into a UPS, which like all things tech - kinda helps smooth out the random chaos of electricity and tech.