Depends on where they are on the spectrum - one of the better salespeople I knew was diagnosed mildly AS. He was extremely smart, had gotten very good at reading people's mannerisms, and didn't get uneasy with that sort of manipulation - it's not a black and white thing.
Granted I'm not a psychologist but am extremely familiar with the literature/research on AS, and everything I can recall promotes a severe disability in recognizing, interacting, and making connections with/between individuals, groups and environments--which is how I would define 'streetsmarts.'
But you're absolutely right in saying that it isn't black and white. There are also plenty of misdiagnosed cases; and the research and criteria continually evolve.
Interesting perspective however.