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Is there the implication that a single concussion could cause long-term neurodegeneration?



In most cases probably not, or if so mild. It depends on the hit, and it depends on the person. It's worth noting the second order effects of mTBI (such as sleep disturbance) can in some cases kick off neurodegenerative processes.[0]

If it's acute (TBI), then almost certainly yes.[1] It's no longer considered a concussion at that point however.

[0] https://www.neuroskills.com/brain-injury/mtbi-and-concussion...

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057689/




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