Fun anecdote: I flew from FL to CA in 2000 for E3 when it was a press-only event. That was the first and last time I've had to have a doctor come to my hotel room (on Day 2 of the show) to give me a shot in the ass for some sort of strep/flu. I forget what it was, or what the shot was, but 18-year-old me sprung back into action the next day... and probably passed whatever I had to every hand I shook.