Well, there are lots of customizations doable (I’m still rocking my .emacs from the 1990’s going through several platforms, Linux→MacOS→Linux, refined over the years with custom functions etc.) but to name a single example:
my keyboard does have a Find key, and I tried mapping isearch-forward to it instead of the default CTRL+S.
That’s trivial, but then, you know how you can press CTRL+S again to go to the next result? Well, that key combo is hardcoded in LISP.
So yes, you technically can remap isearch-forward, but in a useless way.
What HNer henry_flower neglected to state explicitly in his helpful comment is that it is false that pressing C-s to go to the next result is hardcoded in some Emacs Lisp function. I just wanted to say that in case non-Emacsers don't know it's implied by what Henry did say. (What he said is much better than just "that's not true!", he also tells you how to change the C-s key that goes to the next match.)