"In view of the high amount of cytokines induced by SARS-CoV,22, 24 MERS-CoV,25, 26 and 2019-nCoV infections, corticosteroids were used frequently for treatment of patients with severe illness, for possible benefit by reducing inflammatory-induced lung injury. However, current evidence in patients with SARS and MERS suggests that receiving corticosteroids did not have an effect on mortality, but rather delayed viral clearance.27, 28, 29 Therefore, corticosteroids should not be routinely given systemically, according to WHO interim guidance."
Curcumin has been shown to suppress the cytokine storm.
Curcumin is found in the spice turmeric and is available in most grocery stores. Today you can buy a pound of turmeric powder for ~$6. You can buy curcumin tablets in the health & fitness section.
Other anti-inflammatory agents (NSAIDS(aspirin, buprofen, naproxen),prednisone, etc.) are not as effective.
In India children are often given a daily teaspoon of turmeric (curcumin) in milk or water. India suffered much lower SARS deaths (there are confounding factors, e.g. India's high summer heat). I expect the same to happen with covid-19.
Take curcumin papers with a pinch of salt. It's a pan assay interference compound (PAIN), prone to misleading results. Pubmed is full of thousands of papers claiming it solves all manner of medical problems, leading it to be dubbed an 'improbable natural panacea'.
See this article, by the same author as it happens.
This article https://www.sciencedaily.com/releases/2014/02/140227142250.h... by The Scripps Research Institute suggests that cytokine storm is more likely to occur in relatively young patients rather than in the very young or elderly. It further states it was the likely major cause of mortality with the 1918 flu (which killed my great-grandfather), the H1N1 "swine flu", and the H5N1 "bird-flu."
SARS-CoV-19 on the other hand seems to cause mortality more often in patients 55+ years of age rather than the relatively young. At least from the data so far. The NIH emphasized this in yesterday's WH/NIH presser.
"In view of the high amount of cytokines induced by SARS-CoV,22, 24 MERS-CoV,25, 26 and 2019-nCoV infections, corticosteroids were used frequently for treatment of patients with severe illness, for possible benefit by reducing inflammatory-induced lung injury. However, current evidence in patients with SARS and MERS suggests that receiving corticosteroids did not have an effect on mortality, but rather delayed viral clearance.27, 28, 29 Therefore, corticosteroids should not be routinely given systemically, according to WHO interim guidance."
"In most moribund patients, 2019-nCoV infection is also associated with a cytokine storm, which is characterised by increased plasma concentrations of interleukins 2, 7, and 10, ..."
cytochine release syndrome(cytokine storm):
https://en.wikipedia.org/wiki/Cytokine_release_syndrome
Article discussing coronavirus et al and cytochine storm:
"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China"
https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
From the article:
"In view of the high amount of cytokines induced by SARS-CoV,22, 24 MERS-CoV,25, 26 and 2019-nCoV infections, corticosteroids were used frequently for treatment of patients with severe illness, for possible benefit by reducing inflammatory-induced lung injury. However, current evidence in patients with SARS and MERS suggests that receiving corticosteroids did not have an effect on mortality, but rather delayed viral clearance.27, 28, 29 Therefore, corticosteroids should not be routinely given systemically, according to WHO interim guidance."
Curcumin has been shown to suppress the cytokine storm.
https://www.ncbi.nlm.nih.gov/pubmed/25600522/
Curcumin is found in the spice turmeric and is available in most grocery stores. Today you can buy a pound of turmeric powder for ~$6. You can buy curcumin tablets in the health & fitness section.
Other anti-inflammatory agents (NSAIDS(aspirin, buprofen, naproxen),prednisone, etc.) are not as effective.
In India children are often given a daily teaspoon of turmeric (curcumin) in milk or water. India suffered much lower SARS deaths (there are confounding factors, e.g. India's high summer heat). I expect the same to happen with covid-19.