Given that our monitors have outrageous resolutions today, I miss pixel-perfect fonts with good size. I'm getting older and the eyes are not getting any better.
I miss them too. On a 1920x1080 laptop display I can see the grayscale font smoothing as a blur which my eyes try to correct for. In order to make it tolerable I've turned off font smoothing globally. Ugly and jagged text gives me less eyestrain than the built in blurriness of Windows font smoothing.
It's pretty well known that anti-aliasing (and macOS' font rendering) add blur to fonts. A lot of bitmap fonts are "pixel perfect", i.e. there's no blur.
I have great eyesight, because I wear contacts, and I prefer to disable anti-aliasing when I can.