No, you don't have all the issues with traditional NUMA because you aren't doing the same sort of heterogeneous workloads. You're always working on local data, and streaming your outputs to the next layer. This isn't a request-response architecture; such a thing wouldn't scale.
It is more or less the same, it's just that in NUMA you have a limited number of localities, except here it is in the thousands. The issue is one of scheduling that locality. Some process still needs to determine what data is actually local and where it should "flow". Because it can't all fit in one place, the computation needs to be tiled (potentially in multiple ways) and the tiles need to be scheduled to move around in an efficient manner.
