Thanks for the links. This is significantly larger than a NUC, but still manageable. That said, part of what I appreciate about the NUC is that it's all built together...no weird hardware/compat issues, etc.
The weird hw/compat issues tend to be OS-related in my experience. I checked a few of these boards and the integrated graphics tended to be Radeon, but I think it'd really only matter under Linux.