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> While this is probably mostly true, there is good science indicating that certain hormonal portfolios "hold" onto calories better than others.

Yes, that's true, but too many people believe that hormones have a whole number multiplier effect when in fact they probably just nudge TDEE by, what, (off the cuff here) ten percent plus or minus? Maybe less?

Is that enough to significantly reduce a person's margin of error when they're doing CICO, particularly as they get closer to their ideal weight?

Absolutely.

Does that mean they'll get fat eating less than a thousand calories a day because hormones?

Almost certainly not.




But nudging TDEE by 10 percent over the course of a year has a HUGE effect on body composition. Even 0.01% does.




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