It's been a few years since I used Duplicity, and while I liked it, I prefer the Unixy one-thing-well approach of composing several smaller tools to achieve what I need.
The big thing I'm missing from Duplicity are incremental backups, which is not a strong requirement for my use case as bandwidth is cheap and I can delete the oldest N backups to free up space.
But I gain a lot from using a combination of tools: I can easily replace each component, and easily improve my workflow by adding more components, such as deduplication or incremental backups if needed.
https://www.nongnu.org/duplicity/