So how much do you want to limit and punish the accidental death of a friend?
Higher numbers for the previous two will increase cost and death to people who can no longer afford the treatment.
"Least likely" means infinite quality control and is not possible. Failure rate is not zero, you have to pick finite regulatory requirements and financial consequences for failure.
You have to assign a dollar amount to a human life. It is uncomfortable for many people to think big picture thoughts but you're contently using things made by people who have to.
