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I am amazed we somehow found out about all these concoctions. They seem to go so far from the norm without killing you. How are they engineered in the first place?

My moment was not propofol but another medicine for nausea/vomit - it worked in seconds just when I had resigned myself to throw up. I was shocked. How?




5-HT3 antagonism.

https://en.wikipedia.org/wiki/Ondansetron

Usually nausea is caused by the perception that your body "doesn't feel right." Serotonin is responsible for the feeling of wellbeing. Just so happens that subreceptor 3 is more about well being feeling of the body :-)


So that’s why I get nauseous when I’m hungry.




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