I haven't run resident virus scanning for at least a decade or more, including Windows Defender on my Windows machine, and I haven't had a single meaningful issue during that time.
(And I know this with high confidence because I do schedule weekly full disk scans on my computers and NAS and they haven't ever found a damn thing that wasn't a false positive or a fake-positive.)
(And I know this with high confidence because I do schedule weekly full disk scans on my computers and NAS and they haven't ever found a damn thing that wasn't a false positive or a fake-positive.)