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All you've isolated is the placebo effect unless you react that same way to all glutamate containing foods. Chicken broth has tons of glutamate in it, if chicken broth doesn't cause your headaches then neither does MSG. And if you're thinking that the glutamate in chicken broth or other foods could be reacting differently because it's not monosodium glutamate, that's not possible because the instant MSG is dissolved you no longer have MSG, you have sodium ions and glutamate ions. That's chemically the same as the sodium ions and glutamate ions in chicken broth. Glutamate is present in everything from tomatoes, to mushrooms, to parmesan cheese.

Anecdotes are not evidence, and the evidence is clear.




Yea, tomatoes give me sinus headaches too. I don't do broth because of sodium nitrites in the celery have also been a consistent issue. Where does the glutamate come from in broth? I hadn't heard that before.


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I get what you're saying but that's why I used chicken broth as an example as that has tons of free glutamate as well as sodium to go with it. As for free vs. bound glutamate, if it's bound glutamate it's not going to contribute to taste, if you can taste that umami flavor then it's free glutamate you're tasting. (side note, glutamic acid on it's own will dissociate in water just like any other ionic bond, but I get what you mean) And while glutamine or glutamic acid in a protein isn't digested as quickly as free glutamate, it still gets hydrolyzed and given that "MSG syndrome" supposedly lasts for a while it stands to reason that even a slow release over the period of a day should still trigger symptomes given that there's generally a lot more bound glutamate than free glutamate.

But a little free glutamate goes a long way, there's no chinese restaurants just dumping MSG in by the cup, that would be way too over seasoned. I use MSG on a lot of dishes myself and I'll use amounts that have less free glutamate in them than in some other common foods.


> I use MSG on a lot of dishes myself

I use peanut butter myself; people who have problems with it are just a bunch of flakes making it up. My personal experience is all that is real.


The only reason why I mentioned that is to suggest that I know what I proper amount of MSG to add for seasoning is. The amounts in those studies are very excessive and unrealistic.


"The amounts in the studies don't conform to my culinary preferences" doesn't amount to "MSG doesn't cause headaches".

If the small amounts of MSG that you prefer caused headaches in a significant fraction of the general population, it would not be usable at all, and we wouldn't be here talking about it.

There is a combination of circumstances: most people seem to tolerate larger amounts, whereas a few people don't. And, outside of carefully controlled name-brand processed foods, misuse can happen: the problematic quantities are not that far-fetched. A stray teaspoon here or there can be critical.

It's a recipe, pardon the pun, for a controversial issue.


Good point on the rest but it sounds like in this dudes case the evidence is not clear, which makes your conclusion sound ranty compared to the suggestion of a double blind trial.




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