Strangely, I've gone cold turkey off of SSRI's and with the exception of Paxil, have never experienced the Brain Zaps or extreme withdrawal symptoms others report. I wonder why it would vary?
Also, sample size=1, CBD oil for me appears to have many of the anti-anxiety affects that the other SSRI's have provided me, with much less side affects. Although, the dosing is all over the map and varies from manufacturer, so that's a challenge. But it does seem to provide me some relief. I just hope I’m not doing long term damage..
I took myself off my SSRI's about a decade ago, and I experienced the brain/hands/feet zaps, but none of the other symptoms. I'd been on the medication for about 4 years at that time.
I guess genetics are at play. For example, I have a genetic mutation that means I metabolise tricyclics much faster (and tricyclics block the reabsorption of serotonin and norepinephrine, much like SNRIs). Rate of metabolism would affect peak plasma concentrations and half life.
It's quite possible that similar mutations exist that affect SSRI metabolism.
I believe the reason for the variation in discontinuation symptoms between different SSRIs is that half-life of Paxil (paroxetine) is shorter (24h) than that of some of the other drugs in the group such as Prozac (fluoxetine) (2-4 days, and a metabolite is 1-2 weeks.
It is expensive. Usually 45-60 dollars for a months supply.
I’ve used the American Shaman water soluble full-spectrum and Medterra isolate CBD oil. Both were effective for me with a slight preference towards the Medterra isolate.
It’s about the most “normal” feeling I’ve ever had. Definitely by far the most effective treatment I’ve had for anxiety, and that’s including the SSRI’s. Probably beats Lexapro because of the near non-existent side effects for me. But again, sample size 1.
CBD isolate by itself can be a lot cheaper. The cheapest I've found is online from Fully Activated, around $20/g. You should be able to mix your own tinctures with liquid coconut oil, and optionally sunflower lecithin.
Also, sample size=1, CBD oil for me appears to have many of the anti-anxiety affects that the other SSRI's have provided me, with much less side affects. Although, the dosing is all over the map and varies from manufacturer, so that's a challenge. But it does seem to provide me some relief. I just hope I’m not doing long term damage..