Not if you use the Virtualbox extension pack to VNC (that's the free/GPL extension pack, not the Oracle one). That will work with anything. Hell, it'll work with a DOS 1.0 guest.
(and yes, it's VNC, not RDP, I believe the oracle extension pack actually allows for Virtualbox to do RDP as well. But you can stay GPL-only and still support headless VNC. I believe phpVirtualbox uses it with beautiful results)
(and yes, it's VNC, not RDP, I believe the oracle extension pack actually allows for Virtualbox to do RDP as well. But you can stay GPL-only and still support headless VNC. I believe phpVirtualbox uses it with beautiful results)
https://forums.virtualbox.org/viewtopic.php?f=7&t=85886