Have you ever considered whether you suffer from depression and/or anxiety? I was in a similar place after my ADHD diagnosis. Ritalin helped my career greatly, but I was still unsatisfied with life in many ways. After I started taking an antidepressant (Remeron), things got really good for me. I took control of my life and fixed a lot of problems. I find my work and my social relationships more fulfilling. It also fixed my insomnia.
I don’t know the nature of your problems of course, but I found the antidepressant didn’t just make me feel better about things - it also made me better at actually solving my problems.
It fixed my social anxiety and made me better at talking to people, which helped with all sorts of human-related problems. People enjoy my company in social situations, and I enjoy my family’s company (I didn’t really connect with many of them before). I used to think I couldn’t relate to people because I was autistic - maybe I’m on the spectrum, but now that I’m not scared of talking to people and am less of a bummer, I can be friends with all sorts of people.
Also made me less afraid to deal with a bunch of other things I needed to change. It makes things that seemed too hard to bother fixing, suddenly doable. Problems that I used to think of as “facts of life” have been solved.
Of course if you’re dying from a terminal illness or something it’s not going to fix that. And, different antidepressants work for different people, and it’s possible that none will work for you. But there are combinations like Remeron + Effexor (aka “California Rocket Fuel”) that are much more effective if the first attempt fails.