I wrote my dissertation using Pandoc. It might seem that the LaTeX boilerplate is minimal, but Markdown is even more minimal, and it preempts the urge to fuss with your layout. Writing in Markdown means that you can wave your hand at the document and say, "It's a draft, I'll fix the formatting once I'm sure I even want this material." Afterwards, fixing the layout is really easy because you can drop raw LaTeX in wherever you need to, and you haven't wasted countless hours laying out a float you later end up cutting.
