Boring, obvious advice from someone who's been using Kubuntu since Feisty: if it's your main desktop, don't upgrade now unless you have to. For the sake of a couple of weeks' waiting you stand a much better chance of avoiding any teething troubles, or at least being able to to find documentation for your problem. This is especially relevant if you use a laptop or unusual hardware.
(For the record I've been hit with laptop wifi incompatibility (the Intel wireless driver got changed, config files didn't update) and software RAID in the GRUB 2 update.)
For anyone unfamiliar with it, many wifi issues can be taken care of with a little research and the compat-wireless (http://wireless.kernel.org/en/users/Download) downloads. Very easy to patch in the latest drivers for your chipset.
Second that. Unless there's something major you just can't live without, which there doesn't appear to be in the upgrade from 10.04 to 10.10, let the pawns go first.
(For the record I've been hit with laptop wifi incompatibility (the Intel wireless driver got changed, config files didn't update) and software RAID in the GRUB 2 update.)